И вообще, я тут вот третий день медитирую над словами из недавнего обзора
The model that depicts signaling pathways as a linear wiring diagram has been extremely useful to explain the properties of some biological systems; however, a large amount of genetic and biochemical data suggests that the network signaling model is a more complex one. For instance, a genome-wide RNAi screen of ERK/MAPK activity revealed that the contribution of each gene to the signaling output is continuous. In other words, various proteins participate in signal transduction with different levels of contribution.
И потом.
Together, this evidence strongly supports a network view of signal transduction rather than the canonical linear view. Constructing a phosphorylation-based signaling network will greatly help researchers perform a series of global analyses to gain new insights into the organization, specificity, and function of signaling networks.
Мне это напоминает мои детские представления о том, что в клетке все органеллы раскрашены в те же цвета, что в школьном учебнике. Шо правда что ли - кто-то линейные схемы полагает отражающими всю суть процессов в клетке?
no subject
The model that depicts signaling pathways as a linear wiring diagram has been extremely useful to explain the properties of some biological systems; however, a large amount of genetic and biochemical data suggests that the network signaling model is a more complex one. For instance, a genome-wide RNAi screen of ERK/MAPK activity revealed that the contribution of each gene to the signaling output is continuous. In other words, various proteins participate in signal transduction with different levels of contribution.
И потом.
Together, this evidence strongly supports a network view of signal transduction rather than the canonical linear view. Constructing a phosphorylation-based signaling network will greatly help researchers perform a series of global analyses to gain new insights into the organization, specificity, and function of signaling networks.
Мне это напоминает мои детские представления о том, что в клетке все органеллы раскрашены в те же цвета, что в школьном учебнике. Шо правда что ли - кто-то линейные схемы полагает отражающими всю суть процессов в клетке?